ISSCR News
Take Action to Preserve Merit-Based Science and International Collaborations
The White House Office of Management and Budget (OMB) has proposed a new rule titled “Regulation for Federal Financial Assistance” that will significantly reshape how the U.S. government funds and manages scientific research, including international collaborations, through the National Institutes of Health (NIH) and other agencies. All ISSCR members, regardless of whether you are U.S.-based or not, are eligible to provide comment on the proposed policy.
Though the rule is extensive and applies to all federal grantmaking, there are several areas where input from our community is critical.
Vascular Organoid Patches Offer New Hope for Coronary Artery Disease Treatment
Ischemic heart disease (IHD), also known as coronary artery disease, is a leading cause of death and morbidity in western countries. IHD arises when blood vessels of the heart become clogged, blunting oxygen and nutrient supply to heart muscle cells, which eventually die off, leading to heart attack or heart failure. Although larger blood vessels can be replaced surgically to restore blood flow, there is currently no treatment targeting smaller blood vessels, so-called microvessels, which are essential for the uniform blood circulation within the heart muscle.
Yasuhiro Shudo and his team from Stanford University, USA have tested a method to regenerate microvessels in the heart with stem cell-derived vascular organoids. Their work was published today in Stem Cell Reports.
High Fructose During Pregnancy Impairs Stem Cell Function in the Fetal Brain
Nutritional imbalance during pregnancy can have long-lasting effects on the health status and disease susceptibility of the offspring. As such, high fructose intake through sweetened food and beverages in pregnant women has been associated with an increased susceptibility to diabetes and cardiovascular disease, as well as neurological and cognitive impairments in the offspring. Currently, it is not well understood how early life exposure to fructose has such long-lasting effects on the cellular and molecular level.
In a recent paper published in Stem Cell Reports, Hiroya Yamada’s team from Fujita Health University School of Medicine, Toyoake, Japan found that the performance of adult rats in learning and memory tests was impaired when the rats had been exposed to high fructose in before birth by feeding their mothers with high fructose corn syrup
New Podcast Episode. Born Without a Nose
Bosma arhinia microphthalmia syndrome (BAMS) is a rare genetic disorder resulting in babies born without a nose, along with eye and reproductive anomalies. Our guests today investigated the developmental basis of this distinct defect using induced pluripotent stem cells (iPSCs) derived from patients with BAMS. They assess the differentiation potential of BAMS patient-derived iPSCs into cranial placode cells, a group of progenitor cells that contributes to the formation of the nasal epithelium. This allowed them to study the behavior of the nasal epithelial cells during early development. Their work uncovered cellular mechanisms underlying BAMS and provided new insights into the developmental processes that shape the human nose.
Bayer Named Founding Member of the ISSCR Consortium on Advanced Stem Cell-Based Models in Drug Discovery and Development
The International Society for Stem Cell Research (ISSCR) announces today that Bayer is a Founding Member of the ISSCR Consortium on Advanced Stem Cell-Based Models in Drug Discovery and Development, a global cross-sector initiative focused on accelerating the responsible integration of human stem cell-derived models into preclinical drug development.
Co-chaired by Daniela Cornacchia, AstraZeneca, USA, and Shuibing Chen, Weill Cornell Medicine, USA, the consortium is leading a coordinated international effort to advance the regulatory qualification and adoption of human stem cell-derived models, including organoids, engineered tissues, and microphysiological systems, as New Approach Methodologies (NAMs) for drug discovery and development.
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